iotaSciences Updates

Knowledge Insights

The versatility of Cas proteins for DNA editing and beyond

The CRISPR-Cas system is a key gene editing tool that has revolutionised how we manipulate DNA, providing the simplest, most efficient, and adaptable approach yet to making gene edits. These systems – originating in bacteria as a form of adaptive immunity – can be categorised into six types based on...

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A powerful duo – gene-editing meets hiPSCs

Gene editing, especially using the CRISPR-Cas9 system, represents a key technological breakthrough in recent scientific history – but it isn’t the only important advance. Human-induced pluripotent stem cells (hiPSCs) are another powerful tool that has greatly propelled new research and therapeutic strategies in fields including medicine, molecular biology and genetics....

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Gene-editing techniques

Gene editing has rapidly developed over the past decade to become something of a scientific and biomedical revolution. The ability to precisely manipulate the genomes of cells or organisms is a powerful biotechnological tool that has huge potential for treating genetic diseases, creating more resistant crops and improving the efficiency...

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Research Insights

An interview with Dr. Jussi-Pekka Tolonen

“… a new level of confidence in the quality of our cell models.“ Dr. Jussi-Pekka Tolonen is a Marie Skłodowska-Curie Fellow in Professor Esther Becker’s lab at the Nuffield Department of Clinical Neurosciences, University of Oxford. He works on new models of genetic childhood-onset brain diseases. Prior to coming to...

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