Effortless and Automated Single-Cell Cloning

Highly-efficient single-cell cloning with minimal reagent usage

Our automated single-cell cloning instruments deliver a streamlined single-cell cloning workflow featuring ultra-low volume culture chambers.

  • Automate all tedious pipetting steps
  • Confidently document monoclonality with whole-chamber images
  • Maintain exceptional cell viability
  • Easily navigate the entire workflow with intuitive touchscreens
  • Compatible with a wide range of reagents
Feature Cloning Platform Cloning Platform XT
miniature cell chambers
automated plating, feeding, harvesting
whole-chamber imaging for monoclonality assessment
96-well plate integration
X
automated single-cell identification
X
clonality report
X

Cloning Platform

The Cloning Platform provides an ideal solution for medium throughput workflows with a convenient way to assure monoclonality

Cloning Platform XT

The Cloning Platform XT features an integrated 96-well plate, automated single-cell recognition and documentation of clonality

Clone Better with Less

Traditional methods are inherently wasteful

Traditional single-cell cloning methods, such as limiting dilution, are inherently wasteful and inefficient. They require unnecessary large amounts of expensive culture reagents for culturing single cells. Additionally, they lack an easy and reliably way to confirm that only a single cell has been plated in a well. Consequently, time, effort and reagents are indiscriminately applied across all wells, irrespective of knowing which wells contain truly clonal cultures.     

Limiting dilution cloning is wasteful as it requires 100s of µl of costly reagents per well with the majority of wells being non-clonal

Efficient single-cell cloning - miniaturised

Requiring only a fraction of reagents compared to traditional methods, our single-cell cloning instruments deliver market-leading cloning efficiencies across diverse cell types.

From dispensing single cells into miniature low-volume culture chambers, to automatically feeding and harvesting only single-cell chambers, the systems offer a streamlined and easy-to-use way for single-cell cloning. They save costs of expensive reagents and allows researchers to generate more clones with less

Cloning in GRIDs makes it easy to verify which chambers contain a single cell directly after plating, while discarding all non-clonal chambers. It requires only a fraction of reagents compared to other methods.

Consistent performance...

... with up to 25 x more clones per ml of culture medium

Our automated single-cell cloning instruments handle your single cells as gentle as manual pipetting. They require significantly less amount of culture medium to obtain verified clonal cultures. In contrast, manual methods result in highly variable outcomes and lack assurance of clonality.  

Our automation systems deliver highly consistent and reproducible cloning results, while assuring clonality of derived cultures. In contrast, manual methods are highly variable and lack the assurance of clonality. The data shown represents cloning efficiency data for hiPSCs.
Automated single-cell cloning in miniature cell culture chambers provides significantly more clones per ml culture medium compared to traditional limiting dilution cloning in well-plates . The data shown represents the number of clones for hiPSCs.

Learn More

Want to find out more about our single-cell platforms? Contact one of our knowledgeable experts today, visit our resources page, or request a demo to see the platforms in action.